Glioma-Derived TSP2 Promotes Excitatory Synapse Formation and Results in Hyperexcitability in the Peritumoral Cortex of Glioma

Abstract Seizures are common in patients with glioma, especially low-grade glioma (LGG). However, the epileptogenic mechanisms poorly understood. Recent evidence has indicated that abnormal excitatory synaptogenesis plays an important role epileptogenesis. The thrombospondin (TSP) family is a key regulator of synaptogenesis. Thus, this study aimed to elucidate TSP2 epileptogenesis glioma-related epilepsy. expression was increased tumor tissue specimens from LGG patients, and increase may have contributed density spines synapses peritumoral area. A cell-implanted rat model established by stereotactic implantation wild-type TSP2-expressing, TSP2-overexpressing or TSP2-knockout C6 cells into neocortex. Similarly, also observed area implanted tumor. In addition, epileptiform discharges occurred cortex were positively correlated level tissues. Moreover, ?2?1/Rac1 signaling enhanced region, treatment ?2?1 antagonist gabapentin inhibited cortex. conclusion, glioma-derived promotes synapse formation, probably via pathway, resulting hyperexcitability cortical networks, which provide new insight underlying